Modelling the natural disease progression of Alzheimer's disease

 
   Lead Investigator:    Ron Handels
   Institution      :    Maastricht University
   E-Mail           :    ron.handels@maastrichtuniversity.nl
   Proposal ID      :    1113


   Publications:


1  Green C, Handels R, Gustavsson A, Wimo A, Winblad B, Sk^{unicode 00F6}ldunger A, J^{unicode 00F6}nsson L
   Assessing Cost Effectiveness of Early Intervention in Alzheimer's Disease: An Open-Source Modeling Framework
   Journal Article  Alzheimers Dement,15:1309-1321,2019,PMC in process

   PUBLISHED



2  Handels R, J^{unicode 00F6}nsson L, Green C, Vellas B, Eriksdotter M, Fratiglioni L, Wimo A
   Structural uncertainty and cross-validation of decision models in the AD setting: answering questions from policy makers on the reliability of health-economic models
   2019   Abstract  AAIC 2019 , 

   PRESENTED





   Proposal Description:
   Our goal is to develop a model that enables the simulation of the natural disease progression of AD for health-economic decision analytic frameworks. We aim to explore various parametric (survival) models to estimate the natural progression in terms of (changes in) continuous or categorized scores of cognition, behavior, function, and institutionalization and mortality based on a set of (demographic) predictors. We expect these models can be used to address heterogeneity, structural uncertainty and external validity in decision analytic frameworks.